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产品介绍
Clone A16085H
Regulatory Status RUO
Other Names VEGFR2, KDR
Isotype Mouse IgG1, κ
Description CD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane
glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase
2025-05-19receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.
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Verified Reactivity | Human |
Antibody Type | Monoclonal |
Host Species | Mouse |
Immunogen | Recombinant Human VEGFR2-Fc Chimera |
Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
Preparation | The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. |
Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
Application | |
Recommended Usage |
cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. |
Excitation Laser | Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm) |
Application Notes | This clone does not cross-react with mouse endothelial cells. |
RRID | |
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Structure Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1/PDGF receptor family
Distribution | Endothelial cells, embryonic tissues |
Function | VEGFR2 regulates angiogenesis as well as vascular development and permeability. |
Ligand/Receptor | VEGF-A, VEGF-C, and VEGF-D splice isoforms |
Cell Type | Endothelial cells |
Biology Area | Angiogenesis, Cell Biology, Immunology |
Molecular Family | CD Molecules, Cytokine/Chemokine Receptors |
Antigen References | 1. DiSalvo J, et al. 1995. J Biol Chem. 270:7717. 2. McColl BK, et al. 2003. J Exp Med. 198:863. 3. Albuquerque RJ, et al. 2009. Nat Med. 15:1023. 4. Guangqi E, et al. 2012. J Biol Chem. 287:3029. 5. Koch S, and Claesson-Welsh. 2012. Cold Spring Harb Perspect Med. 2:a006502. 6. Munaut C, et al. 2012. Plos One. 7:e33475. 7. Wehland M, et al. 2013. Int J Mol Sci. 14:9338. |
Gene ID |
Purified anti-human CD309 (VEGFR2), PE anti-human CD309 (VEGFR2), APC anti-human CD309 (VEGFR2), PE/Cyanine7 anti- human CD309 (VEGFR2), Brilliant Violet 421 anti-human CD309 (VEGFR2), PE/Cyanine5 anti-human CD309 (VEGFR2),
PE/Dazzle 594 anti-human CD309 (VEGFR2)
Product Data
HUVEC cells were stained with CD309 (clone A16085H) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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For Research Use Only. Not for diagnostic or therapeutic use.
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