KEL Biotech™白喉毒素变异体蛋白CRM197

关键词：Diphtheria toxin, DT, NAD(+)--diphthamide ADP-ribosyltransferase, Diphtheria toxin fragment A, Diphtheria toxin fragment B, CRM197, Nontoxic Diphtheria Toxin，重组CRM197蛋白，白喉毒素

一、产品描述

CRM197是一种将52位的甘氨酸替换为谷氨酸的单一突变的无毒性的白喉毒素突变体，致使白喉毒素酶活性位点发生改变，从而不能对细胞产生毒性作用，但在抗原性和免疫原性上仍和天然白喉毒素保持一致。CRM197是一种研究明确的蛋白质，作为多糖和半抗原的载体使其具有免疫原性。它被用作一种载体蛋白，用于许多已经被批准的疫苗，比如脑膜炎球菌、乙型流感嗜血杆菌和肺炎球菌感染的结合疫苗。

二、蛋白详情

Recombinant CRM197 (Nontoxic Diphtheria Toxin) (YXX05401)

表达系统：E. coli

形态：Lyophilized

纯度：>90% as determined by SDS-PAGE.

UniProt：P00587

应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

注意：仅供科研使用

三、已发表文献

Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. PMID: 17988701

Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. PMID: 20082134

Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway. PMID: 30374472

Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications. PMID: 21715186

Overexpression and purification of the recombinant diphtheria toxin variant CRM197 in Escherichia coli. PMID: 21889551

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